Webinar

Webinar on Understanding the Cleaning Phenomena

in API Plants to enable cleaning by design

7th November at 9 am (UK time)

 

The turnaround of multipurpose API plant between different products is slow, with much time required for cleaning and validation of cleanliness. The opportunity is to reduce the required time significantly, improving plant availability. Our central hypothesis is that cleaning/decontamination for plant turnaround can be substantially improved by the use of better mechanistic understanding and appropriately chosen measurements. Better scientific understanding of cleaning phenomena will allow the design of more targeted and efficient approaches. Current practice in the design of cleaning protocols is based on past history and relatively weak understanding of the controlling phenomena.

In this webinar, we give a broad overview of the ongoing Cleaning Project under the Pharma Innovation Programme Singapore (PIPS) consortium. We briefly discuss some of the approaches to determine relevant material properties of APIs such as high-throughput solubility, strength of surface adhesion and deposition. Other aspects discussed will include the design and construction of a novel flow rig to observe tokens under plant-realistic cleaning conditions, evaluation of analytical technologies such as UV-Vis and Fluorescence spectroscopy for rinse sample monitoring, and novel inspection technologies such as the use of borescope and associated image analysis.

Overall, this webinar will provide a flavor of the many scientific approaches which are currently being taken as part of our project to acquire a better understanding of the cleaning phenomena.

 

This webinar will be presented by Karthick Murugappan, ICES, Singapore and should last no longer than one hour.

If you wish to register please contact Christine Stevenson on Christine.stevenson@strath.ac.uk

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