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At Hunan University we consider the involvement with CPACT as a super opportunity to apply our chemometric methods to complex industrial problems as well as develop research in areas of data analysis and modelling to meet the ever-growing industrial needs in spectroscopic process analytical technologies.

Dr Zengping Chen

CPACT related research interests

1. Research team

  • Professor Ruqin Yu
  • Professor Hailong Wu
  • Dr Zengping Chen

2. Research interests:

The State Key Laboratory of Chemo/Biosensing and Chemometrics (CBSC) was formed at Hunan University in 2001.  It brings together analytical chemists, physical scientists, biochemists and chemometricians to research solutions to generic problems in the fields of on-line monitoring of chemical and pharmaceutical processes, biochemical & biomedical analysis and environmental monitoring. The Chemometrics group in the CBSC has over 20 years of research expertise in Chemometrics and has developed a number of effective methods for the analysis of complex data sets.

 

2.1 Fundamental research programmes

  1. Process analytical technology and compensating for nonlinear effects in process spectroscopic data for improved process monitoring and control;
  2. The maintenance of multivariate calibration models;
  3. Novel second-order linear calibration methods for three-way data arrays produced by HPLC-DAD, GC-MS and excitation-emission fluorescence spectrophotometer.

2.2 Selected Achievements

  1. Designed a series of novel second-order linear calibration methods (ATLD, SWATLD etc.) for the analysis of three-way data arrays produced by HPLC-DAD, GC-MS and excitation-emission fluorescence spectrophotometer.
  2. Developed smoothed window factor analysis (SWFA) and recursive evolving spectral projection (RESP) for the resolution of complex overlapping chromatographic peaks.
  3. Devised loading space standardization (LSS) to integrate spectroscopic data with process variables such as temperature. Through the application of LSS, multivariate calibration models built at temperatures other than those of the test samples can provide predictions with accuracy comparable to the results obtained at a constant temperature.
  4. Proposed a new methodology termed smoothed principal component analysis (SPCA) to improve the sensitivity of X-ray diffraction spectroscopy for the in-situ determination and monitoring of crystal morphology. SPCA can significantly improve the signal to noise ratio and hence lower the detection limits thereby providing an important contribution to crystallization process performance monitoring.
  5. Invented optical path length estimation and correction (OPLEC) to correct multiplicative light scattering effects due to the changes in optical path length caused by the physical variations inherent within the individual samples. OPLEC was observed to effectively mitigate the detrimental effects of physical light scattering and significantly improve the prediction accuracy of the calibration models for NIR spectra of powder blending processes and Raman spectra of suspension samples.
  6. Developed a new strategy called systematic prediction error correction (SPEC) for the maintenance of the predictive abilities of multivariate calibration models when e.g. the spectrometer or measurement conditions are altered. SPEC is simple to implement and requires less information than other calibration transfer methods, which offers advantages for applications with limited data.

 

  • Near Infrared Spectroscopy
  • Raman Spectroscopy
  • Advanced Calibration Methods for Multiphase Systems
  • Novel Calibration Transfer Methods

General contact information

Web http://www-en.hnu.edu.cn/
Web http://cbsc.hnu.cn/

CPACT contact information

Please note that this contact information is for CPACT related enquiries only.

Dr Zengping Chen

Telephone 0086 (0) 731 88821916
Fax 0086 (0) 731 88821916
email zpchen2002@hotmail.com

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