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"The UK needs a more integrated approach to research in process analysis and control engineering and this is what CPACT is all about. I want to be part of an organisation that breaks down the barriers between engineers and measurement scientists, tackles complex industrial problems through multi-disciplinary research and generally, elevates industry - university collaboration to an exciting new level"

Professor David Littlejohn

CPACT related research interests

Strathclyde is working on process analysis techniques with particular emphasis on the Chemicals and Pharmaceutical industries.

The following recent projects involve staff and students from the departments of Pure & Applied Chemistry, Chemical and Process Engineering, Strathclyde Institute of Pharmacy and Biomedical Sciences, Electronic and Electrical Engineering, and Mathematics:

• Comparison of transmission and back scattered Raman spectroscopy for the analysis of powders and tablets

• Comparison of near infrared spectrometry, Raman spectrometry and acoustic emission for the non-invasive monitoring of powder blending

• Development of methodologies for the real-time monitoring of powder drying with emphasis on effects on particle size

• Developments in MIR-ATR probe technology based on polycrystalline silver halide optical fibres

• Development of optical interfaces for the non-invasive monitoring of microflow reactors by Raman spectrometry

• Comparison of calorimetry and NIR/MIR spectrometry for reaction monitoring

• Evaluation of techniques for on-line and non-invasive monitoring of fermentation processes

• In-situ characterisation of polymer stabilized pigment dispersions using spectroscopic techniques

• Modelling of acoustic wave permeation through reactor walls leading to the modelling and construction of new transducers for non-invasive monitoring of heterogeneous reaction processes by acoustic emission

• Developments in calibration transfer algorithms for application in process analysis

• Investigations of particulate processes and the effects that scattering has on NIR spectra

• Development of low-field NMR spectrometry for process analysis

• Developments in Chemometric calibration methodology using a DoE approach

• In-situ monitoring of crystallisation processes

• Optical property measurements using Integrating Sphere:

• Total Diffuse Transmittance, Total diffuse Reflectance, Collimated Transmittance in conjunction with the inverse Adding-Doubling method to extract bulk absorption and scattering properties.

• Physical information (refractive index, particle size, shape and microstructure): Using Mie theory for spherical and T-matrix method or Raleigh-Gans approximation for non-spherical particles.

• On-line implementation using a flow through system is being planned.

• Optical property measurements using spatially resolved system (reflectance at multiple source to detector distances). A spatially resolved spectrometer system has been built in-house – capable of up to 9 simultaneous measurements.

• Faster measurements than the integrating sphere method.

• Easier to implement online/inline/in-vivo measurement system.

• Novel semi-empirical methodologies for scatter correction in order to improve the performance of calibration models for estimating chemical properties.

• Application of these methodologies to emulsions and emulsion polymerisation, Fermentation reactions, powder mixtures.

• Mass Spectometry

• Calibration Transfer Algorithms

• Acoustic Techniques

• Particle Size Analysis

• Particle Image Analysis

• Laser Induced Fluorescence

Additional expertise in atomic spectrometry, XRF spectrometry and chromatography, dynamic light scattering measurement, laser diffraction measurement, surface enhanced Raman spectroscopy, surface plasmon spectroscopy.

General contact information

Telephone 0141 548 2067
Fax 0141 548 4212

CPACT contact information

Please note that this contact information is for CPACT related enquiries only.

Professor David Littlejohn

Dr Alison Nordon

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