CPACT Webinar on
Leaning toward PAT?
Overview and Applications of Lean
Chemometrics
Adam J. Rish, Sentronic and Sam Henson,
SciY
26th March 2026 at 3pm (UK
time)
The adoption of
spectroscopic process analytical technology (PAT) by the pharmaceutical
industry has accelerated in recent years to become an essential aspect of
modern pharmaceutical manufacturing. However, spectroscopic PAT deployment is
stifled, in part, by the high calibration burden of conventional chemometric
techniques that are required to extract relevant information from the spectral
PAT data. The high calibration burden is driven by the exceptional expense and
limited availability of active pharmaceutical ingredient (API) material needed
to generate enough representative calibration samples, particularly in the
early stages of drug development. This may discourage the application of PAT in
some circumstances and often limits utilization to late in the manufacturing
process development lifecycle. Lean chemometrics offers an alternative to
conventional chemometric by leveraging time-saving, material-sparing, and
cost-cutting strategies to reduce the calibration burden of developing the
chemometrics for a PAT analytical method. The deployment of lean chemometrics
with spectroscopic PAT for extracting chemical information and developing
process insights from the spectral data has seen increasing interest in the
pharmaceutical industry.
The webinar will
cover the definition and scope of lean chemometrics, highlighting the benefits
and intended applications of these techniques. An overview of chemometric
techniques considered as lean will be provided alongside case studies that
leveraged lean chemometrics to reduce the calibration burden of spectroscopic
PAT in pharmaceutical manufacturing.
This webinar
will last no longer than one hour.
Please register directly at https://universityofstrathclyde.webex.com/weblink/register/r8fe3e6c034f1b7d09993bc7de13c700f