CPACT webinar on
Enabling PAT Deployment with Lean
Chemometrics
Adam J. Rish,
Sentronic and Sam Henson, SciY
18th June
2026 at 4pm Singapore time, 9am UK time
Spectroscopic process analytical
technology (PAT) is an essential aspect of modern pharmaceutical manufacturing
that routinely provides substantial returns-on-investment (ROI). However,
adoption of PAT is not as prominent across the pharmaceutical industry due to,
in part, the high calibration burden of developing the necessary chemometrics
for proper data analysis. The calibration burden of conventional chemometric
techniques used for PAT is driven by factors such as limited material
availability and extended analytical development timelines. This may discourage
the application of PAT in some circumstances and often limits utilization to
late in the manufacturing process development lifecycle. Lean chemometrics
offers an alternative to conventional chemometric by leveraging time-saving,
material-sparing, and cost-cutting strategies to reduce the calibration burden
of developing the chemometrics for a PAT analytical method. These techniques
are intended for deployment as fit-for purpose strategies, emphasizing that the
chemometric analysis should meet the particular needs of the specific
application without excessive complexity or resource investment. Lean
chemometrics can enable rapid PAT deployment and maximize the ROI of utilizing
spectroscopic PAT during pharmaceutical manufacturing.
The webinar covers the definition
and scope of lean chemometrics, with emphasis on the benefits and utility of
these techniques. The PAT applications that may benefit from deploying lean
chemometrics in a fit-for-purpose capacity are discussed, with example case
studies showing how lean chemometrics were leveraged to reduce the calibration
burden of spectroscopic PAT in pharmaceutical manufacturing.
This webinar will last no longer
than one hour.
Please register at: https://universityofstrathclyde.webex.com/weblink/register/r4c5d6b19c7056db3e0e7cf7fe73ebdfc